Patrick McManus, who was aged 60 and had worked as a nurse for more than 40 years, died at Royal Stoke University Hospital on Sunday.
He was a popular and valued member of staff, University Hospitals of North Midlands NHS Trust (UHNM) said.
The trust said his “big, Irish personality will be sorely missed” by friends and colleagues.
Tracy Bullock, chief executive of UHNM, said: “He was a loveable character and brought kindness and compassion to all his patients which was acknowledged by the number of compliments and thank you messages he received.
“He was an exceptional leader and took staff and students under his wing.”
Ms Bullock said her thoughts were with his family and paid tribute to his “many years of invaluable service”.
Mr McManus was originally from Ireland and had worked in Stafford for about 10 years, previously working at North Staffordshire Royal Infirmary in Stoke.