At around 7.20am, police were called to a report collision involving one vehicle on the A513 in Stafford.
Off-duty emergency services staff who were passing provided medical assistance until colleagues from West Midlands Ambulance Service arrived.
Two ambulances, a paramedic officer and the Midlands Air Ambulance from Cosford were sent to the scene.
Ambulance service staff were told that the driver appeared to have had a medical episode at the wheel and took over treatment providing advanced life support to the patient.
Sadly, it was not possible to save the man and he was confirmed dead at the scene. His family are being supported by specialist Police officers.
The road has now reopened.
An investigation is underway and anyone with information or anyone who may have dash-cam footage is asked to call 101 quoting incident number 93 of 15 August